serum nfl concentrations  (Gilead Sciences)

Journal: European Journal of Neurology

Article Title: Serum glycobiomarkers for chronic inflammatory demyelinating polyneuropathy

doi: 10.1111/ene.70023

Figure Lengend Snippet: Characteristics of patients with CIDP and healthy controls.

Article Snippet: The serum NfL protein concentrations were measured in duplicate using the Simoa HD‐1 Analyzer (Quanterix, Lexington, MA, USA) and ultrasensitive paramagnetic bead‐based enzyme‐linked immunosorbent assay as performed by researchers blinded to all clinical data.

Techniques: Control, Sampling

Journal: Science Translational Medicine

Article Title: Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19

doi: 10.1126/scitranslmed.abi7643

Figure Lengend Snippet: ( A ) Comparison of serum NFL between healthy controls (Controls, N = 55) and hospitalized patients with COVID-19 (mean NFL per patient, N = 142). Bars represent mean NFL concentrations with 95% CIs. Statistical differences were assessed using a stratified van Elteren Wilcoxon rank sum test, where the test was stratified by both age as a four-level categorical variable (based on sample quartiles) and sex. **** P < 0.001. ( B ) Serum NFL in 35 patients to highlight the range of NFL concentrations in longitudinally collected samples. The first and last NFL concentrations are indicated by a black and red dot, respectively, and mean concentrations for each patient are presented by the small black solid horizontal lines. ( C ) Serum NFL trends over time in the 35 patients with COVID-19 with longitudinal blood draws and for whom at least one NFL measurement is at least 3 SDs above the group mean of NFL in control individuals. NFL concentrations are shown on the base 10 logarithmic scale. The NFL concentration representing the mean control NFL + 3 SDs is indicated by a solid blue horizontal line.

Article Snippet: In our cohort of patients with COVID-19, a tendency of lower serum NFL concentrations was seen with the use of remdesivir compared to its non-use.

Techniques: Concentration Assay

Journal: Science Translational Medicine

Article Title: Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19

doi: 10.1126/scitranslmed.abi7643

Figure Lengend Snippet: Comparison of serum NFL between healthy controls and patients with COVID-19. In unadjusted analyses, P values result from a Wilcoxon rank sum test. In adjusted analyses, P values result from a stratified van Elteren Wilcoxon rank sum test, where the test was stratified by both age as a four-level categorical variable (based on sample quartiles) and sex. N/A, not applicable.

Article Snippet: In our cohort of patients with COVID-19, a tendency of lower serum NFL concentrations was seen with the use of remdesivir compared to its non-use.

Techniques:

Journal: Science Translational Medicine

Article Title: Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19

doi: 10.1126/scitranslmed.abi7643

Figure Lengend Snippet: Associations between serum NFL and outcomes in patients with COVID-19. For descriptive summaries of NFL concentration and for ease of presentation, LOS was categorized using the sample median, whereas mRS at discharge was categorized using a predefined cutoff of interest. Associations of intubation, ICU admission, LOS, and mRS at discharge (all as independent variables) with NFL concentration (as the dependent variable) were evaluated using linear regression models (for the continuous mean NFL per patient, minimum NFL per patient, and maximum NFL per patient variables) and logistic regression models (for the binary occurrence of an NFL value >25th percentile and occurrence of an NFL value >75th percentile variables). Regression coefficients are interpreted as the change in the mean NFL outcome measure (on the natural logarithmic scale) corresponding to the presence of the given characteristic (intubation and ICU admission), to each doubling of LOS, and to each 1-unit increase in mRS at discharge. CI, confidence interval; CKD, chronic kidney disease. P values <0.0025 were considered as statistically significant after applying a Bonferroni correction for multiple testing.

Article Snippet: In our cohort of patients with COVID-19, a tendency of lower serum NFL concentrations was seen with the use of remdesivir compared to its non-use.

Techniques: Concentration Assay

Journal: Science Translational Medicine

Article Title: Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19

doi: 10.1126/scitranslmed.abi7643

Figure Lengend Snippet: Comparison of serum NFL concentrations according to COVID-19 treatment. Regression coefficients, 95% CIs, and P values result from linear regression models, where NFL was the dependent variable. Regression coefficients are interpreted as the difference in mean NFL concentration (on the natural logarithmic scale) between patients who had the given treatment and patients who did not have the given treatment. P values <0.0063 were considered as statistically significant after applying a Bonferroni correction for multiple testing.

Article Snippet: In our cohort of patients with COVID-19, a tendency of lower serum NFL concentrations was seen with the use of remdesivir compared to its non-use.

Techniques: Concentration Assay